Influenza case definitions – optimising sensitivity and specificity

Influenza case definitions - optimising sensitivity and specificity.

Clinical case definitions used for surveillance struggle to satisfy two challenging and potentially conflicting needs – sensitivity and specificity. A more sensitive case definition is useful to estimate disease burden and identify outbreaks. It will identify a larger proportion of the true cases, but often at the cost of finding a large number of cases due to other causes. A more specific case...

Assessing Sensitivity and Specificity of Surveillance Case Definitions for Zika Virus Disease

We evaluated performance of 5 case definitions for Zika virus disease surveillance in a human cohort during an outbreak in Singapore, August 26-September 5, 2016. Because laboratory tests are largely inaccessible, use of case definitions that include rash as a required clinical feature are useful in identifying this disease.

Evaluating Case Definitions for Clinical Influenza Surveillance

Performance of case definitions for influenza surveillance.

Influenza-like illness (ILI) case definitions, such as those from the European Centre for Disease Control and Prevention, World Health Organization (WHO) and United States Centers for Disease Control and Prevention, are commonly used for influenza surveillance. We assessed how various case definitions performed during the initial wave of influenza A(H1N1) pdm09 infections in Singapore on a coho...

Sensitivity And Specificity Of Procalcitonin In Diagnosis Of Neonatal Sepsis

  Background and Objective: According to the fact that neonatal infection is a challenging diagnosis field, several studies have tried to test sensitivity and specificity of diagnostic tests. This study was conducted to evaluate the sensitivity and specificity of procalcitonin (PCT) as a single early marker of neonatal sepsis. Materials and Methods: In this study, 150 neonates admitted to NIC...